60924 - Banka S, Roberts R, Plews D, et al. Vitamin B12 deficiency in infants secondary to maternal causes. Oral Versus Intramuscular Cobalamin Treatment in Megaloblastic Anemia: A Single-Center, Prospective, Randomized, Open-Label Study. 43997 - Bolaman Z, Kadikoylu G, Yukselen V, et al.

Vitamin B12 (cobalamin) deficiency in elderly patients. 43996 - Andres E, Loukili NH, Noel E, et al.

Neuropsychiatric disturbances in presumed late-onset cobalamin-C disease. 33669 - Roze E, Gervais D, DemeretS, et al. Therapeutic approaches to cobalamin-C methylmalonic academia and homocystinuria.

33668 - Bartholomew DW, Batshaw ML, Allen RH, et al. Remethylation defects: guidelines for clinical diagnosis and treatment. 33667 - Ogier de Baulny H, Gerard M, Saudubray JM, et al. Long-term outcome in treated combined methylmalonic academia and homocystinemia. 33666 - Andersson HC, Marble M, Shapira E. 33665 - Hydroxocobalamin injection package insert. West Conshohocken, PA: BTG International, Inc. † Off-label indication Revision Date:, 01:56:53 PM References 33229 - Cyanokit (hydroxocobalamin) package insert. Specific guidelines are not available it appears that no dosage adjustments are needed. Specific guidelines for dosage adjustments in renal impairment are not available it appears that no dosage adjustments are needed. In studies, oxalate crystals have been found in the urine of both healthy patients and those being treated for cyanide poisoning. Hydroxocobalamin and cyanocobalamin are excreted unchanged in the urine. Specific guidelines for dosage adjustments in hepatic impairment are not available it appears that no dosage adjustments are needed. Therapeutic Drug Monitoring Maximum Dosage Limitsģ0 mcg/day IM, followed by 200 mcg/month IM is FDA-approved maximum however, doses up to 2,000 mcg/day IM are used off-label 10 g IV (total dose) for cyanide poisoning.ġ00 mcg/day IM, followed by 50 mcg/month IM is FDA-approved maximum however, doses up to 2,000 mcg/day IM are used off-label 140 mg/kg (Max: 10 g) IV total dose has been used off-label for cyanide poisoning. 1,000 mcg IM once is the flushing dose for Schilling test/vitamin B12 absorption test.

Hydroxocobalamin cyanide antidote kit